OHDSI Symposium​ 'Scaling up Reliable Evidence across Europe' June 3rd, 2024

The fifth European OHDSI Symposium called "Scaling up Reliable Evidence Across Europe" aimed to bring data partners, regulators, and researchers to collaborate and share results and ideas about the use of the OMOP-CDM in Europe.

The main symposium took place on Monday, June 3rd 2024 at the ship SS Rotterdam. Saturday June 1st, and Sunday June 2nd were dedicated to workshop and workgroup meetings, held in the Education Centre of the Erasmus University Medical Center, Rotterdam.

The symposium had 360 participants, 25 plenary presentations, 130 posters, and 13 software demos.

Video Recordings can be found on the OHDSI YouTube Channel.

Slides

Video

Description

Photo

 

SESSION ONE

00:00 - Welcome to the European OHDSI Journey

Peter Rijnbeek, PhD, Chair, Department of Medical Informatics, Erasmus MC

14:00 - Journey of OHDSI: Where Have We Been and Where We Can Go Together?            

Patrick Ryan, PhD, Janssen Research and Development, Department of Biomedical Informatics, Columbia University Medical Center

42:45 - Selection of European Initiatives Using the OMOP CDM

Moderator: Renske Los, PhD, Assistant Professor of Medical Informatics, Department of Medical Informatics, Erasmus MC

  1. 43:33 - OHDSI Europe National Nodes building opportunities through collaboration - Renske Los, Erasmus MC, The Netherlands
  2. 1:05:00 - ONCOVALUE: Can Real-World Data Shape the Future of Health Technology Assessment in Oncology? - Andreas Henriksen, Copenhagen University Hospital, Denmark 
  3. 1:12:17 - DigiONE: technical challenges and solutions to the European cancer OMOP conversions from hospital EHR - Piers Mahon, DIGICORE, UK
  4. 1:22:10 - The PHEMS Project: New Strategies in Health Data Sharing - Sofia Bazakou, The Hyve, The Netherlands
  5. 1:28:00 - Ecraid: European Clinical Research Alliance on Infectious Diseases - Ankur Krishnan, Heidelberg University Hospital, Germany
  6. 1:40:10 - PHederation - the Federated Network of Pulmonary Hypertension Registries - Eva-Maria Didden, Actelion, a Johnson & Johnson Company, Belgium 
  7. 1:48:05 - Q&A


 

SESSION TWO

09:00 - Collaborator Showcase: Rapid Fire Presentation 

Moderator: Katia Verhamme, MD, Associate Professor of Use and Analysis of Observational Data, Department of Medical Informatics, Erasmus MC, Rotterdam.

  1. 10:08 - Adoption of the OMOP Common Data Model in the UK
    Speaker: Alex Knight, Health Data Research UK
  2. 15:39 - Piloting the Transformation of Multiple Sclerosis Real-World Data to the OMOP CDM: Lessons Learned
    Speaker: Tina Parciak, UHasselt 
  3. 21:45 - Annotation-preserving machine translation of English corpora to validate Dutch clinical concept extraction tools
    Speaker: Tom Seinen, Erasmus MC
  4. 28:49 - Beyond Diagnostic Codes: A Weakly Supervised learning Framework for Accurate Multimorbidity Identification in Electronic Health Records
    Speaker: Luz Saúde, Portugal
  5. 34:05 - OHDSI meets Flowise to Streamline Biomedical Data Discovery and Analysis
    Speaker: João Almeida
  6. 38:16 - ReportGenerator: Automating study reports and visualization apps for DARWIN EU® research
    Speaker: Cesar Barboza Gutierrez, Erasmus MC
  7. 45:00 - Analysis of Lung Cancer Patient Treatment with Immune Checkpoint Inhibitors Using Natural Language Processing for Data Extraction from Electronic Health Records
    Speaker: Clara L. Oeste and Annelies Verbiest, Lynxcare
  8. 54:14 - An Exploration of Ovarian Cancer Therapy Sequence Utilization in Treatment-naive Women from 2008-2020
    Speaker: Whitney Burton, Taipei Medical University 
  9. 1:02:10 - Baseline Characterization and Treatment Pathways of Patients With Alport Syndrome Across Geographies: Exploring a Rare Disease in Multi-Database Retrospective Cohort Study
    Speaker: Katrin Manlik, Bayer AG

 

 

SESSION THREE

06:55 - Large Scale Evidence Generation in EHDEN and DARWIN EU®

Moderators: Daniel Prieto-Alhambra and Katia Verhamme, Department of Medical Informatics, Erasmus MC

  1. 06:55 - Introduction to EHDEN - Daniel Prieto Alhambra
  2. 10:15 - Predicting long term cancer survival for Health Technology Assessment: A Multinational Cohort Study Across Europe - Jeremy Dietz, National Institute for Health and Care Excellence 
  3. 20:05 - Trends over time in medicines with suggested shortages in Europe - Marta Pineda-Moncusi, Oxford University
  4. 29:05 - Q&A
  5. 35:10 - Introduction to DARWIN EU® - Katia Verhamme
  6. 40:20 - DARWIN EU®- Trend of prescription opioid use in Europe - Annika Jödicke, Oxford University
  7.  53:05 - DARWIN EU®- Treatments of multiple myeloma in Europe from 2012-2022: a population-based network cohort study - Talita Duarte Salles, Erasmus MC
  8. 1:04:10 - Q&A

1:09:00 - What evidence are we going to showcase at OHDSI Europe in 2025?

Patrick Ryan, Johnson & Johnson, Columbia University 

1:32:00 - Closure

Peter Rijnbeek, PhD, Chair, Department of Medical Informatics, Erasmus MC

Workshops

Part 1

Part 2

Vocabulary Workshop Part 1 and 2
What you need to know about OHDSI Vocabularies to do phenotyping? 

When: June 2nd, 10:00-15:00

Faculty: Vlad Korsik, Anna Ostropolets, Christian Reich, Patrick Ryan, Tatiana Skugarvskaya, Oleg Zhuk 

Description: The OHDSI Standardized Vocabularies is a mandatory reference standard in the OMOP CDM and enables standardized and robust research in the OHDSI Network. They are instrumental in identifying patients of interest, constructing features and navigating the results of studies. To use them to their full capacity, researchers need to know how to operate them and how to mitigate their shortcomings. This tutorial aims to describe the use of Vocabularies for phenotyping, specifically: 

  • Develop concept sets from code lists in the literature 
  • Make concept sets comprehensive  
  • Simplify the concept set construction through the hierarchy (SNOMED, RxNorm, ATC and other hierarchies) 
  • Use tools for all this and more.

  Target Audience: Anyone interested in using the vocabularies 

 
 

Introduction to OHDSI tutorial 

When: June 1st, 10:00-12:30

Faculty: Aniek Markus, Renske Los

Description:

  • History & philosophy behind OHDSI
  • How does the community work
  • What can currently be done with the OHDSI tools
  • What does it take to be able to use the tools
  • Where and how can you learn more about OHDSI

Target Audience: Anyone new to OHDSI, interested in data standards, methods research, open-source development or clinical evidence generation.

 

Open-source Development Workshop

When: June 1st, 10:00-12:30

Faculty: Adam Black, Cesar Barboza, Maarten van Kessel

Description: Introduces participants to the OMOP CDM and how to contribute to the OHDSI community. Participants will learn practical skills, related to the OHDSI ecosystem and how to contribute meaningfully to ongoing projects. By the end of the workshop, attendees will be equipped with the knowledge to actively participate in the OHDSI community, enhancing both the tools and research impacting real-world health outcomes. 

Target Audience: Designed for beginners with no prior coding experience, the session covers the basics of using open-source software to engage in collaborative health data science. 

 

Phenotyping Workshop 

When: June 1st, 13:30-15:00

Faculty: Katia Verhamme, Talita Duarte-Salles

Description

  • What is a phenotype?
  • Why do we need phenotypes?
  • How to create a phenotype in ATLAS

Target Audience: Anyone new to cohort building in ATLAS

 

HADES Workshop

When: June 1st, 13:30-17:00

Faculty: Martijn Schuemie, Egill Fridgeirsson 

DescriptionTutorial on how to use the HADES tools to query databases, create cohorts and perform simple characterizations. 

Target Audience: Anyone new to HADES and interested to use the tools. Good to have some familiarity with R.

Workgroups

The workgroups were not recorded, as they were designed to be informal.

Natural Language Processing Workgroup

When: June 1st, 15:30-17:00

Lead: Tom Seinen

Oncology Workgroup

When: June 1st, 15:30-17:00

Lead: Asieh Golozar

National Node Meetings

When: June 2nd, 10:00-12:30

Academy Hackathon

When: June 2nd, 13:30-15:00

Lead: Henrik John, Renske Los

Extract Transform Load Workgroup

When: June 2nd, 15:30-17:00

Lead: Maxim Moinat, Anne van Winzum, Melanie Philofsky


 Patient-Level Prediction

When: June 2nd, 15:30-7:00

Lead: Ross Williams, Egill Fridgeirsson

Symposium Booklet

The booklet can be found: here.

It includes information about the:

  • Symposium Agenda
  • Symposium Sponsors
  • Software Demonstrations
  • National Nodes
  • Poster Presentations
  • Workshop and Workgroup Agenda

Posters

Pdfs can be viewed by clicking on the poster title

Open-Source Analytics Development 

1 

The DARWIN EU® Data Network 

Maxim Moinat, Montse Camprubi, Sofia Bazakou, Anne van Winzum 

2 

DARWIN EU® - Trends of prescription opioid use in Europe  

Junqing Xie, Mike Du, Yuchen Guo, Cesar Barboza, James Brash, Antonella Delmestri, Talita Duarte-Salles, Jasmin Gratton, Romain Griffier, Raivo Kolde, Wai Yi Man, Nuria Mercade-Besora, Marek Oja, Sarah Saeger, Katia Verhamme, Dina Vojinovic, Edward Burn, Daniel Prieto-Alhambra, Martí Català, Annika M. Jödicke 

3 

DARWIN EU® - Risk of Thromboembolic Events Associated With COVID-19 During the Omicron Period, and SARS-CoV-2 Vaccination 

Xintong Li, Annika Jodicke, Katia Verhamme, Mees Mosseveld, James Brash, Sarah Seager, Laura Pérez Crespo, Nuria Mercade Besora, Talita Duarte Salles, Marek Oja, Raivo Kolde, Edward Burn, Albert Prats-Uribe, Daniel Prieto Alhambra, Marti Catala-Sabate 

4 

DARWIN EU® - Age-specific burden of RSV-related disease in Europe  

Johnmary Arinze, Miguel-Angel Mayer, Guillaume Verdy, Maarten van Kessel, Juan Manuel Ramírez-Anguita, Angela Leis, Romain Griffier, Marek Oja, Raivo Kolde, Antonella Delmestri, James Brash, Laura Pérez-Crespo, Talita Duarte-Salles, Katia Verhamme 

5 

DARWIN EU® - Drug utilisation study of medicines with prokinetic properties in children and adults diagnosed with gastroparesis 

Dina Vojinovic, Johnmary Arinze, Antonella Delmestri, James Brash, Sarah Saeger, Guillaume Verdy, Núria Mercadé, Talita Duarte-Salles, Mees Mosseveld, Miguel-Angel Mayer, Katia Verhamme 

6 

DARWIN EU® - Characterization of Patients with Chronic Hepatitis B and C 

Dina Vojinovic, Johnmary Arinze, Cesar Barboza Gutierrez, Antonella Delmestri, James Brash, Sarah Seager, Vianney Jouhet, Guillaume Verdy, Mees Mosseveld, Miguel-Angel Mayer, Angela Leis, Juan Manuel Ramírez-Anguita, Raivo Kolde, Katia Verhamme 

7 

Forecasting the prescription rates of antibiotics in the UK between 2013 to 2023 incorporating the impact of COVID-19  

Yuchen Guo, Edward Burn, Daniel Prieto-Alhambra, Marta Pineda-Moncusí 

8 

CdmOnboarding R package for data quality assessment  

Sofia Bazakou, Maxim Moinat, Anne van Winzum 

9 

Trends over time in medicines with suggested shortages in Europe  

Marta Pineda-Moncusi, Mees Mosseveld, Edward Burn, Dani Prieto-Alhambra, Theresa Burkard 

10 

The HMA-EMA Real-World Data Catalogues of data sources and studies: Facilitating data sources discoverability to support research and regulatory decision making 

Catarina Moura, Elpida Kontsioti, Jasmine Gratton, Stefania Simou, Paolo Alcini 

11 

Harmonization to the OMOIP CDM of cancer patient data at the Modena Oncology Center 

Enrico Calanchi, Luca Moscetti, Mirko Orsini, Laura Delsante, Enrica Martinelli, Andrea Spallanzani, Federica Bertolini, Elisa Pettorelli, Massimo Dominici 

12 

OMOPification of real-world cancer data to enable privacy-preserving analytics for cancer research: an implementation at the Maastricht University Medical Centre+ for the Digital Oncology Network for Europe 

Prabash Galgane Banduge, Anne-Lore Bynens, Cédric Gillissen, Alberto Traverso, Petros Kalendralis, Andre Dekker, Lizza Hendriks, Aiara Lobo Gomes

13 

A potentially scalable, sustainable and secure architecture to deploy and maintain ETL pipelines and OHDSI tooling for ECRAID-Base 

Marc Padros Goossens, Frank Leus, Ben Burke, Tom Feusels, Jared Houghtaling, Freija Descamps, Lauren Maxwell and Ankur Krishnan 

14 

Universal Patient Trajectory Extraction from OMOP CDM 

Markus Haug, Raivo Kolde 

15 

Enhancing Clinical Data Management and Utilization with the Data2Evidence Platform 

Karthik Seetharaman, Santan Maddi, Satish Anbazhagan, Afreen Sikandara, Brandan Tan, Alicia Jing Wen Koh, Peter Hoffmann 

16 

Harmonizing Public Research Access Datasets for AI Advancements in Asthma/ COPD Diagnosis 

Frédéric Jung, Vangelis Sakkalis, Chang Sun, Mahmoud Ibrahim, Gökhan Ertaylan 

17 

Automation of STCM Vocabularies Review in OMOP CDM 

Wai Yi Man, Antonella Delmestri 

18 

Development of an Automated and (near) Real-Time (ART) OMOP-CDM ETL System in Taiwan 

Alex PA. Nguyen, Muhammad Solihuddin Muhtar, Min-Huei Hsu, Chih-Wei Huang, Jason C. Hsu 

 
 

Observational Data Standards and Management

19 

Additional technical data protection measures to improve the security of an OMOP/OHDSI infrastructure 

"Francesco Pozzoni, Matteo Gabetta, Mauro Bucalo, Anna Alloni, Giorgia Masina, Maurizio Pastore, Lucia Sacchi, Nicola Barbarini" 

20 

The PHEMS project: New Strategies in Health Data Sharing - Clinical Use Cases 

Guus Wilmink, Sofia Bazakou, Lydia Briggs, Roger Domingo Espinos, Aida Felipe Villalobos, Katariina Gehrmann, Liam Glueck, Yolanda Jordan Garcia, Jan Willem Kuiper, Jennifer McIntosh, Cristina Ruiz Herguido, Andrew Taylor, Marja Vaitinen, Arnau Valls Esteve, Gary Zhen Yuan Liew, Azadeh Tafreshiha 

21 

Towards all-Island sharing of Irish lymphoid blood cancer data: Landscape and gap analysis 

Kluivert Boakye Duah, Michael Quinn, Eva Szegezdi, Lisa Crawford, Aedin C. Culhane, Mark Lawler, Siobhan Glavey, Ruth Clifford, Ian M. Overton 

22 

Expanding the OUH Clinical Data Warehouse data delivery infrastructure with OMOP CDM and OHDSI tools 

Olivier Bouissou, Dan Johansen, Elisabeth Ross 

23 

Lessons Learned from EHDEN Data Partner Reviews: Improving ETL Processes and Data Quality in OMOP CDM Conversions 

Evanette K Burrows, Clair Blacketer, Erica A Voss, Frank J DeFalco, Dmitry Dymshyts, Patrick B Ryan  

24 

An Exploration of Ovarian Cancer Therapy Sequence Utilization in Treatment-naive Women from 2008-2020 

Whitney Burton, Quynh Nguyen, Mohammad Solihuddin Muhtar, Christianus Heru Setiawan, Septi Melisa, Jason Hsu 

25 

Cloud-based, Automated Solution to Transforming Clinical Datasets to the OMOP CDM 

Simon Thompson, Abigail Carter, Remi Shah, Adam Bekele, Myles Jones 

26 

Automated OMOP-CDM pipeline for the new EBMT Registry  

Shirah Cashriel, Nir Assaraf, Ignacio Garcia, Fernando Cid, Freija Descamps  

27 

Standardization of the French national database SNDS in OMOP-CDM 

Gaëlle Collumeau, Cécile Charles, Lorien Benda, Elena Mylonas, Axelle Menu, Gil Lampe, Stéphanie Combes 

28 

eHealth-Hub For Cancer –OHDSI for Cancer on the Island of Ireland 

eHealth-Hub for Cancer Consortium, Ruth Clifford, Katie Crowley, Shirin Moghaddam, William Waston, Clare Donohoe, Eva Szegezdi, Siobhan Galvey, Mary Cahill, Ken Mills, Michael Quinn, Ian Overton, Mark Lawler, Aedin C. Culhane 

29 

FHIN (Federated Health Innovation Network) 

Camille Deltomme, Kim Denturck, Peter De Jaeger, Wouter Willems, Bram De Caluwe, Geert Hellebaut, Noëlla Pierlet, Karel Van Brantegem, Peter Heirman, Yves Thorrez, Mieke Deschepper 

30 

Is it necessary to include SNOMED CT national extensions in ATHENA? Struggling with adaptation from BIFAP data model to OMOP CDM 

Juan Ignacio Díaz-Hernández, Hermenegildo Martínez-Alcalá, Cristina Justo-Astorgano, Ana Llorente, Arturo Álvarez, Miguel Ángel Macía 

31 

National Drug Code (NDC) code reuse: scope of the problem and methods to solve. 

Dmitry Dymshyts, Clair Blacketer, Evanette K Burrows, Anna Ostropolets, Erica A Voss 

32 

Predicting Colorectal Cancer Liver Metastases using TMUCRD-Mapped OMOP CDM 

Yudha E. Saputra, Daniel C.A. Nugroho, Muhammad Solihudin, Jason C. Hsu  

33 

Creating clinically meaningful cancer groups from SNOMED for care systems and care quality research: a head and neck case study 

Hayley Fenton, Elisabeth Ross, Elin Hallan Naderi, Anne-Lore Bynens 

34 

Improving vocabulary mapping to OMOP-CDM concepts: an AI-based automated and collaborative mapping platform 

João Fonseca, António Bezerra, Gonçalo Teixeira, Miguel Rebelo, Madalena Plácido, Ana Costa, Ivan Pereira 

35 

Deployment approach for first phase of OMOP CDM harmonization and network study participation at CuSL 

Lars Halvorsen, Joëlle Thonnard, Aline Van Maanen, Audrey Timmermans, Yannick Barussaud, Alix Collard, Emma Gesquire, Ben Burke, Mahsa Maleki Nazari, Shirah Cashriel 

36 

Expanding the Treatment Episode concept in the Observational Medical Outcomes Partnership Common Data Model - Experience from Real-World data modelling in the ONCOVALUE collaboration 

Andreas Henriksen, Juho Lähteenmaa, Cecilie Koefoed-Nielsen, Samu Eränen, Andrea Roncadori, Ilaria Massa, Andreas Bjerrum 

37 

ETL for OMOP CDM v5.4 of large-scale population data using Databricks and Apache Spark 

Silvia Jimenez, Mehrdad A. Mizani, Shirah Cashriel, Emma Gesquiere, Jadene Lewis, Angela Wood, Rouven Priedon, Anne Li 

38 

First steps towards a Danish ICU Data and Research Platform 

Kaas-Hansen BS, Placido D, Thorsen-Meyer H-C, Perner A 

39 

A Modular ETL Framework for Standardized Data Model Conformance in Oncology Real-World Evidence Generation  

Danial Kamran, Lisa Merker, Guillaume Azarias, Stefan Schilling 

40 

Mapping NHS Cancer Records to OMOP 

Laura Kerr, Abigail Carter 

41 

SNOMED overhaul and its impact on ETL and phenotypes 

Masha Khitrun, Alexander Davydov, Oleg Zhuk 

42 

Adoption of the OMOP Common Data Model in the UK 

Alex E. Knight, Paola Quattroni, David Seymour, Monica Jones, Geoff Hall, Sam Cox, Uwaye Ideh, Emily Jefferson 

43 

DATOS-CAT: Leveraging OMOP-CDM for the standardization, integration and analysis of population-based biomedical data in Catalonia 

Judith Martinez, David Sarrat-González, Xavier Escribà-Montagut, Aikaterini Lymperidou, Alberto Labarga 

44 

Patient-Level data export based on ATLAS Cohort Definitions 

Marc Olivé, Sandra Pulido, Gabriel Maeztu 

45 

Lessons Learned Mapping UK Pain Datasets to the OMOP Common Data Model 

Gordon Milligan, Erum Masood, Phil Appleby, Phil Quinlan, Sam Cox, Armando Mendez Villalon, Tom Giles, Calum MacDonald, Christian Cole 

46 

Conversion of the Rheumatology Department Data to the OMOP Standard in a Dutch Hospital. 

Manon Merkelbach, Tim Jansen, Piet V Riel, Ruud Simons, Menno Hoogeveen 

47 

Using OHDSI standards to host Longtidinial Mental Health Data in a staging database for pushing into OMOP: Lessons from the INSPIRE network Datahub  

Bylhah Mugotitsa, Agnes Kiragga, Jim Todd, Jay Greenfield, Michael Ochola, Evans Omondi, Tathagata Bhattacharjee, David Amadi, Dora Mailosi 

48 

Conversion of the Papageorgiou General Hospital EHR to the OMOP Common Data Model 

Grigoris Papapostolou, Achilleas Chytas, Alexandros Rekkas, Maria Bigaki, Demetrios Zeimpekis, Lampros Dermentzoglou, George Tortopidis, Pantelis Natsiavas 

49 

Enhancing Healthcare Insights: OMOP Harmonization and Integration of Surgical Procedure Database into EHDEN with BC Platforms' Solutions 

Mai TN Nguyen, Stefano Gamage, Serena Ciaburri, Kalle Pärn, Viktoria Sassi-Prantner, Hang T.T. Phan  

50 

Improving completeness in mapping cancer registry data to OMOP CDM by using alternative source fields 

Tapio Niemi, Eloïse Martin, Vincent Faivre, Patrick Arveux, Simon Germann, Valérie Pittet, Jean-Luc Bulliard 

51 

Piloting the Transformation of Multiple Sclerosis Real-World Data to the OMOP CDM: Lessons Learned 

Tina Parciak, Kirstin Tümler, Alexander Stahmann, Emma Gesquiere, Freija Descamps, Liesbet M. Peeters 

52 

Enhancing Real-World Clinical Data Analysis: Integrating NLP-derived results with OMOP CDM 

Mónica Arrúe, Mariona Forcada, María Quijada, Paula Chocrón, Gabriel de Maeztu 

53 

Expanding the OMOP Common Data Model to support Extracorporeal Life Support research 

Clemens Rieder, Oleg Zhuk, Ahmed Said, Peta M.A. Alexander, Dominik J. Hoechter 

54 

How metadata empowers MedDRA hierarchies and mappings 

Mikita Salavei, Oleg Zhuk, Vlad Korsik, Alexander Davydov 

55 

Custom vocabulary management in ETL 

Tatsiana Skuhareuskaya, Vlad Korsik, Vojtech Huser, Alexander Davydov 

56 

Transforming Clinical Trial Data to the OMOP CDM  

Cynthia Sung, Mike Hamidi, Zhen Lin, Tom Walpole, Rebecca Baker, Melissa Cook, Shital Desai, Priya Gopal, Dan Hartley, Priya Meghrajani, Tra Nguyen, Paul Orona, Katy Sadowski, Sebastiaan van Sandijk, Philip Solovyev, Ramona Walls, Kenneth J. Wilkins, Qi Yang, the Clinical Trial Working Group  

57 

Enhancing Neuropsychiatric Data Integration with OMOP: A Comprehensive Landscape Analysis by the OHDSI Psychiatry Working Group 

Polina Talapova, Dmytro Dymshyts, Andrew E. Willams, Piper A. Ronallo, Shilpa Ratwani, Callum Harding, Dong Yun Lee, Tatiana Skugarevskaya  

58 

Defining international approaches for the detection of emergent metastasis and the classification of site of metastasis from hospital EHR  

Stelios Theophanous, Sue Cheeseman, Elin Hallan Naderi, Elisabeth Ross, Anne-Lore Bynens, Prabash Galgane Banduge, Petros Kalendralis, Aiara Lobo Gomes, Piers Mahon 

59 

Real-World Hospital Data Integration Processes and Clinical Information System Architectures across European Comprehensive Cancer Centres (ONCOVALUE) 

Kevin Tittel, Nora Franzen, Louise Janssen, Wim van Harten, Valesca Retèl 

60 

Leveraging FHIR for a generic EHR to OMOP-ETL: can we make an ETL process reusable? 

Sebastiaan van Sandijk, Renske Los 

61 

“Health Orphans” - Rare diseases on their way to OMOP and into clinical trials 

Michele Zoch, Ines Reinecke, Christian Gierschner, Richard Gebler, Romina Blasini, Josef Schepers, Martin Sedlmayr 

62 

Integration of Clinical and Genomic Data Mapped to the OMOP Common Data Model in a Federated Data Network in Belgium 

Tatjana Jatsenko, Murat Akand, Joris Robert Vermeesch, Dries Rombaut, Michel Van Speybroeck, Martine Lewi, Valerie Vandeweerd 

63 

VALO Feasibility Study on the OMOP CDM Maturity in the Nordic Countries 

Persephone Doupi, Gustav Klingstedt, Saara Malkamäki, Markus Kalliola, Heidi Hakala, Mikko Kaasinen, Janne Kauhanen, Erika Natunen, Pasi Rikala, Anna Virtanen, Elina Sarpola  

 

Clinical Applications

64 

ONCOVALUE - Implementing value-based oncology care at European cancer hospitals 

Mads Andersen, Juho Lähteenmaa, Johanna Mattson, Ulrik Lassen, Andreas Bjerrum 

65 

The Mystery of PHQ-9 Questionnaires’ Predictive Accuracy 

Yonatan Bilu, Tal El Hay 

66 

Institute of Analytics for Health 

M. Borshchivska, A. Kanfoud, T. Helleputte 

67 

Analysis of Lung Cancer Patient Treatment with Immune Checkpoint Inhibitors Using Natural Language Processing for Data Extraction from Electronic Health Records  

Iege Bassez, Laura Deckx, Vincent Geldhof, Annelies Verbiest, Shahbaz Pervaiz, Dries Hens, Philip Debruyne, Christof Vulsteke, Clara L. Oeste 

68 

PHederation – the Federated Network of Pulmonary Hypertension Registries 

Eva-Maria Didden, Valerie van Baalen, Michel van Speybroeck, Monika Brand 

69 

Longitudinal trajectories of polypharmacy in older people, and their association with the risk of mortality: A joint latent class model analysis of real-world data from the UK and the Netherlands 

Leena Elhussein, Ross D Williams, Wai Yi Man, Edward Burn, Antonella Delmestri, Victoria Y Strauss, Daniel Prieto-Alhambra 

70 

Deep learning for patient-specific modelling of Acute Myeloid Leukemia based on longitudinal clinical laboratory data and the OMOP common data model 

Eric Fey, Salma Rachidi, Alexey Ryzhenkov, Valtteri Nieminen, Tomi Mäkelä, Oscar Brück, Kimmo Porkka 

71 

Harmonising Surgical Data: Experience from the Hip Fracture Mini Federated Network of Registries 

Marissa G. Fiorello, Kristin Kostka, Justin Manjourides, Xavier L. Griffin, Jennifer C.E Lane 

72 

Using Real-world to Unlock the Potential of Artificial Intelligence in Enhancing Diagnostic-Therapeutic Care Pathways in Pediatrics 

Diana Ferro, Silvia Capuzzi, Francesco Fabozzi, Antonella Cacchione, Andrea Carai, Alberto Tozzi, Angela Mastronuzzi 

73 

An Industry Partner experience of an EHDEN multi-country federated study characterising an alopecia areata cohort 

Abaigeal Jackson, Genevieve Gauthier, Griffith Bell, Ioannis Biblias, Jimmy Toulas, Yi-Chien Lee, Erwin Bruninx 

74 

Adaption of the OMOP CDM for Rheumathology: A Portuguese experience. 

Catarina Tomé, Enrico Calanchi, Laura Delsante, Ângela Afonso, Daniel Silva, Ana Rita Lopes, João Eurico Fonseca 

75 

IODA, an ATLAS-based software for the INAH Community 

A. Kanfoud, M. Borshchivska, T. Helleputte 

76 

Incorporating Temporal Electronic Health Records (EHRs) into Clinical Prediction Models 

Estelle Lampel, Aniek Markus, Tom Seinen 

77 

An international multi-centre federated-network data analysis using routine health data investigating disparities in care for patients with scaphoid fractures.  

Usama Rahman, Gongliang Zhang, Benjamin Martin, Paul Nagy, Avi Giladi, Dawn Laporte, DS Edwards, Xavier Griffin, Jennifer Lane 

78 

Developing a Clinical Decision Support System Software Prototype that Assists in the Management of Patients with Self-Harm based on the use of national registries harmonized in OMOP CDM: the PERMANENS Project. 

"Philippe Mortier, Franco Amigo, Madhav Bhargav, Susana Conde, Montserrat Ferrer, Oskar Flygare, Busenur Kizilaslan, Laura Latorre Moreno, Angela Leis, Miguel Angel Mayer, Víctor Pérez Sola, Ana Portillo van Diest, Juan Manuel Ramírez-Anguita, Ferran Sanz, Gemma Vilagut, Jordi Alonso, Lars Mehlum, Ella Arensman, Johan Bjureberg, Manuel Pastor, Ping Qin " 

79 

Baseline Characterization and Treatment Pathways of Patients With Alport Syndrome Across Geographies: Exploring a Rare Disease in a Multi-Database Retrospective Cohort Study  

Katrin Manlik, Glen James, Andrea Scalise, Charlie Scott, Daloha Rodriguez Molina, David Vizcaya 

80 

Challenges in harmonising data across multiple biobanks  

Karyn Mégy, Rebecca Akhanemhe, Ben Hollis, Ali Abbasi, Amanda O’Neill, Shikta Das, Stewart MacArthur, Sean O’Dell, Sebastian Wasilewski, Quanli Wang, Slavé Petrovski, Jen Harrow 

81 

The Paradox of Precision Medicine - Challenges and approaches to solutions at Oslo University Hospital 

Elin Hallan Naderi, Elisabeth Ross 

82 

Enhancing Pediatric Care Data Collaboration through Privacy-Enhanced Federated Learning and Anonymization 

Timo Miettinen, Mehreen Ali, Tuomo Pentikäinen 

83 

Prediction of Incident Dementia Among Chronic Disease Patients: A Multi-Cohort Multi- Center Observational Patient-Level Prediction Study 

Phan Thanh-Phuc, Sunny Lin, Daniel C.A. Nugroho, Muhammad Solihuddin Muhtar, Nguyen Phung-Anh, Seng Chan You, Christine Y. Lu, Nicole Pratt, Jason Hsu 

84 

Characterization of Heavy Menstrual Bleeding in 11 data sources from 9 countries using OMOP-CDM: a European Health Data Evidence Network study 

Marta Pineda Moncusí, Siir Su Saydam, George Argyriou, Ronald Herrera, Eric Fey, Kimmo Porkka, Angela Leis, Miguel Angel Mayer, Juan Manuel Ramírez-Anguita, Zsolt Bagyura, Loretta Kiss, Peter Rijnbeek, Marcel de Wilde, Saeed Hayati, Hedvig Nordeng, Nhung Trinh, Asieh Golozar, Mariana Schiffer Acar, Bettina Althoff, Carina Dinkel-Keuthage, Carsten Moeller, Gianmario Candore 

85 

Standardizing European sarcoma registry data to the OMOP Common Data Model: the retroperitoneal sarcoma use case 

Peter Prinsen, Paolo Lasalvia, Roberto Lillini, Vittoria Ramella, Anna Alloni, Joanna Szkandera, Espen Enerly, Maaike van Swieten, Siri Larønningen, Julien Bollard, Audrey Pons, Thomas Gaudin, Claire Chemin-Airiau, Alric Sans, Jean-Yves Blay, Arnaud Malfilatre, Danielle Newby, Gijs Geleijnse, Annalisa Trama 

86 

Daily dose assessment of medicines administered in intensive care unit and inpatient settings in a general hospital 

Juan Manuel Ramírez-Anguita, Miguel A. Mayer, Angela Leis, Martí Català 

87 

External Validation of the Revised Cardiac Risk Index (RCRI) Clinical Prediction Model in observational health care databases 

Alexander Saelmans, Evan Minty, Peter Rijnbeek, Jenna Reps, Ross Williams 

88 

Implementation and Updating of Artificial Intelligence Clinical Prediction Models: a Systematic Review 

Alexander Saelmans, Tom Seinen, Victor Pera, Aniek Markus, Egill Fridgeirsson, Henrik John, Peter Rijnbeek, Jenna Reps, Ross Williams 

89 

The association between comorbid depression and insulin initiation in type 2 diabetes: A cohort OHDSI study 

Christianus Heru Setiawan, Daniel C.A. Nugroho, Phan Thanh-Phuc, Septi Melisa, Muhammad Solihuddin Muhtar, Nguyen Phung-Anh, Jason C. Hsu 

90 

OHDSI in Africa and Partnerships with European Institutions 

Cynthia Sung, Agnes Kiragga, Kofi Agayre, OO Aluko, Daniel Ankrah, Chidi Asuzu, Adam Bouras, Geert Byttebier8, Aize Cao, Ahmed El-Sayed, Chris Fourie, Nega Gebreyesus, Jay Greenfield, Lars Halvorsen, Jared Houghtaling, Katherine Johnston, Andrew S. Kanter, Mack Kigada, Sylvia Muyingo, Henry Ogoe8, Bolu Oluwalade, Mariette Smith, Amelia Taylor, Marleen Temmerman, Jim Todd, Marc Twagirumukiza, Daniel M Wanga, Andrew Williams, the OHDSI Africa Chapter 

91 

Imminent Subsequent Fractures In Postmenopausal Women With Fragility Fractures: Incidence And Patient Characteristics From Six European Countries 

Xihang Chen, Trishna Rathod-Mistry, Gianluca Fabiano, Antonella Delmestri, Alireza Moayyeri, Joshua Warden, Carlen Reyes, James Brash, Katia Verhamme, Mees Mosseveld, Sarah Seager, Rafael Pinedo-Villanueva, Eng Hooi Tan 

92 

The risk of immune- and inflammatory post-acute sequelae of COVID-19 (PASC): a network study in 6 European countries, the US, and Korea 

Theresa Burkard, Kim López-Güell, Martí Català, Raivo Kolde, Anneli Uusküla, Daniel Dedman, Jessie O Oyinlola, Juan Manuel Ramírez-Anguita, Miguel A. Mayer, Talita Duarte-Salles, Laura Pérez-Crespo, Alicia Abellan, Kristin Kostka, Núria Mercadé-Besora, Lourdes Mateu, Cora Loste, Roger Paredes, Mees Mosseveld, Jaime Meléndez-Cardiel, Nhung TH Trinh, Hedvig ME Nordeng, Chungsoo Kim, Ji-Woo Kim, Dominique Delseny, Gregoire Mercier, Edward Burn, Antonella Delmestri, Wai Yi Man, Annika M Jödicke, Daniel Prieto-Alhambra, Junqing Xie 

 

Methodological Research

93 

Dimension Reduction Techniques for Clinical Prediction Models using Electronic Health Record data 

Roëlle Bänffer, Aniek Markus, Tom Seinen 

94 

Context: the value of matched sampling for large-scale characterisation during phenotype diagnostics 

Edward Burn, Mike Du, Yuchen Guo, Núria Mercadé-Besora, Albert Prats-Uribe, Daniel Prieto-Alhambra, Martí Català 

95 

Exploring Embedding Representations for Structured Data in the OMOP CDM: Use-Case for Long Hospitalization Prediction 

Jorge Cerejo, Simão Gonçalves, Bernardo Neves, José Maria Moreira, Nuno A. da Silva, Francisca Leite 

96 

Transforming lung cancer EHR data into the OMOP CDM: A case study of Non-Small Cell Lung Cancer  

Evangelos Chandakas, Ping Sun 

97 

OMOP concept code selection with GPT-4 

Vita De Vos, Michiel Larmuseau, Jana Labeau, Nicky Van Der Vekens, Peter De Jaeger 

98 

Predicting long term cancer survival for Health Technology Assessment: A Multinational Cohort Study Across Europe  

Jeremy Dietz, Ian Koblbauer, Ravinder Claire, James Love-Koh, Jamie Elvidge, Irene López-Sánchez, Laura Pérez-Crespo, Anna Palomar Cros, Asieh Golozar, Antonella Delmestri, George Corby, Marta Alcalde Herraiz, Abigail Robinson, Marti Catala Sabate, Edward Burn, Wai Yi Man, Xihang Chen, Miguel-Angel Mayer, Juan Manuel Ramirez Anguita, Maria Angeles Leis Machin, Nicola Symmers, Mahéva Vallet, Colin McLean, Peter Hall, Mees Mosseveld, Katia Verhamme, Espen Enerly, Peter Prinsen, Jelle Evers, Marek Oja, Raivo Kolde, Eric Fey, Tiago Taveira Gomes, Alberto Moreno Conde, Evelyne Fournier, Tommi Kauko, Rafael Marcos Gragera, Talita Duarte Salles, Dalia Dawoud, Danielle Newby  

99 

A collaborative neuroscience research program on Cluster Headache across a standardized health data network 

Christian Laut Ebbesen, Kristine Harrsen 

100 

Evaluating Regulatory Actions with Time Series Methods: A Study on Fluoroquinolones Usage in UK Primary Care and Hospitals 

Yuchen Guo, Berta Raventós, Leena Elhussein, Kim López-Güell, Eng Hooi Tan, Martí Català, Albert Prats-Uribe, Dan Dedman, Wai Yi Man, Hezekiah Omulo, Antonella Delmestri, Jennifer Lane, Usama Rahman, Xavier Griffin, Chuang Gao, Christian Cole, Patrick Batty, John Connelly, Helen Booth, Alison Cave, Katherine Donegan, Daniel Prieto-Alhambra, Edward Burn, Annika M. Jödicke 

101 

Exploring Drug Utilization Patterns in Osteoporosis Therapy 

Balqis Istiqomah Gusbela, Septi Melisa, Ming-Hung Teng, Daniel C.A Nugroho, Jason C. Hsu 

102 

Structured and unstructured data from first and second line care combined in OMOP datawarehouses 

T. Helleputte, M. Borshchivska, A. Kanfoud, G. Vanhalst, T. Klein, P. Olivier 

103 

Transfer learning for rare disease prediction 

Luis H John, Jenna M Reps, Egill A Fridgeirsson 

104 

Advancing Certification and Evaluation of Medical Device Software in the EU using OMOP 

Frédéric Jung, Chang Sun, Mahmoud Ibrahim, Gökhan Ertaylan 

105 

Method for Discovering Cohort-based Trajectories from OMOP CDM  

Kunnar Kukk, Angela Kannukene, Sulev Reisberg 

106 

Advancing Value-Based Cancer Care: BC Platforms' Systematic Approach to OMOP Oncology Federated Query and Analytical Solutions in the ONCOVALUE consortium 

Mai TN Nguyen, Inka Lehtonen, Kalle Pärn, Mark Heffernan, Anni Ahonen-Bishopp, Hang T.T. Phan 

107 

Cancer Survival: A Multinational Cohort Study Using the OMOP Common Data Model 

Irene López-Sánchez, Laura Pérez-Crespo, Ravinder Claire, Anna Palomar, Ian Koblbauer, Jeremy Dietz, Jamie Elvidge, James Koh, Asieh Golozar, Juan Manuel Ramírez-Anguita, Angela Leis, Miguel-Angel Mayer, Nicola Symmers, Mees Mosseveld, Espen Enerly, Peter Prinsen, Jelle Evers, Marek Oja, Raivo Kolde, Eric Fey, Tiago Taveira-Gomes, Alberto Moreno Conde, Evelyne Fournier, Kauko Tommi, Dalia Dawoud, Rafael Marcos Gragera, Talita Duarte Salles, Danielle Newby 

108 

Trade-offs in the design of explainable prediction models for health care 

Aniek F. Markus, Jan A. Kors, Katia M.C. Verhamme, Peter R. Rijnbeek 

109 

Preparatory work for efficient mapping of Hungarian drug codes 

Ágota Mészáros, Tibor Héja, Zsolt Bagyura 

110 

The Onco Health Data Dock: A Data Lake for Real-Time Mapping and Harmonization in Pediatric Oncology 

Diana Ferro, Silvia Capuzzi, Francesco Fabozzi, Antonella Cacchione, Andrea Carai, Alberto Tozzi, Angela Mastronuzzi 

111 

Beyond Diagnosis Codes: A Weakly Supervised Learning Framework for Accurate Multimorbidity Identification in Electronic Health Records 

Bernardo Neves, Jorge Cerejo, Simão Gonçalves, José Maria Moreira, Nuno A. da Silva, Francisca Leite, Mário J. Silva 

112 

Excess healthcare cost associated with chronic diseases. A comparative study among nine European countries 

Boris Polanco, Diana Pacheco Barzallo, Ana Lucía Oña Macías  

113 

Annotation-preserving machine translation of English corpora to validate Dutch clinical concept extraction tools 

Tom M Seinen, Jan A Kors, Erik M van Mulligen, Peter R Rijnbeek 

114 

Common Data Environment and ICD family mappings implications 

Irina Zherko, Oleg Zhuk, Vlad Korsik, Timur Vakhitov, Alexander Davydov 

 

 Software Demonstrations

Software Demonstrations

ARACHNE Data Node and Execution Engine runtime to enable network studies

Alexey Manoylenko 

The MOMIS platform: semantic integration and machine learning to improve the OMOP CDM harmonisation process

Enrico Calanchi

OHDSI meets Flowise to Streamline Biomedical Data Discovery and Analysis

 João R. Almeida

CohortSymmetry: an R package for Prescription Sequence Symmetry Analysis using the OMOP CDM

Xihang Chen 

omock: an R package for creating mock data in the OMOP CDM format for software testing

Mike Du 

omocept: an R package for querying and visualising omop ConceptS (removing the CONS)

Andy South

CohortConstructor - an R package to build and curate cohort tables

Nuria Mercade-Besora

dsOMOP: Federated Analysis of Harmonized Clinical Data Combining OMOP CDM and DataSHIELD in a DATOS-CAT Cohort Use Case

David Sarrat-González

DataSHIELD and OHDSI - an opportunity?

Jacek Chmiel

Empowering research with seamless data flow and research-ready, anonymised data in OMOP CDM: Learnings from the design of WAYFIND-R, a global precision oncology registry and research platform

Tom Stone

CohortSurvival: an R package for survival analysis using the OMOP CDM

Kim López Güell

ReportGenerator. Automating study reports and visualization apps for DARWIN EU® research

Cesar Barboza Gutierrez

 

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